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Smith was a A graduate of the [[Wikipedia:Tuskegee University|Tuskegee Institute]] and , Smith then went on to attend [[Wikipedia:Meharry Medical College|Meharry Medical College]], after which he established a medical practice in Pensacola.

In 19181912, Smith was commissioned served as a first lieutenant in president of the Medical Reserve Corps Pensacola Negro Business League, an affiliate of the UNational Negro Business League established by [[Wikipedia:Booker T.SWashington|Booker T. ArmyWashington]] in 1900.<ref>"Doings Smith was instrumental in organizing Washington's [[March 1]], [[1912]] visit to Pensacola, presiding over the capacity crowd event at Meharry College." Nashville Globe. 15 March 1918the [[Pensacola Opera House]].</ref>

In 1918, Smith had was commissioned as a first lieutenant in the Medical Reserve Corps of the U.S. Army.<ref>"Doings at Meharry College." Nashville Globe. 15 March 1918.</ref> That same year, Smith's daughter, Lorine, who died of typhoid fever in 1918, at the age of just 20.<ref>Florida Certificate of Death for Lorine E. Smith</ref>