- 1821 – Transfer of Spanish West Florida to the United States: Andrew Jackson and his wife Rachel set out for Pensacola.
- 1856 – A groundbreaking was held in Pensacola commencing construction of the Alabama & Florida Railroad.
- 1861 – Civil War: Fort Pickens was reinforced by several hundred Federal troops aboard the Brooklyn.
- 2002 – Frank Patti pleaded guilty to charges of tax fraud.